Old Kampala Senior Secondary school is a mixed O and A level school. It is located on Old Kampala Hill near the historical Fort Kampala, Old Kampala Police Station, on Old Kampala Road off Namirembe Road. The school acutally lies where two hills meet.

Old Kampala Senior Secondary school is a Government Indian founded school and it is as old as the Indian settlement in Uganda.As the Indian settlement grew and prospered, the need for its own system of education became a necesity. The arrival of two brothers: Mr. K.D Gupta and Mr.B.D Gupta from Bengal India-an ancient seat of learning, coincided with the needs of the allien community.Unlike their counterparts in trading, the Guptas were teachers and they initiated the setting up of the school and Mr. K.D Gupta became its first headmaster.

The school began to grow in fame and size and this campus became small.to accomodate the influx of the students. A new site at Kololo(current Kololo Senior Secondary School) was opened as its annex under the same administration and the same teachers taught there.